BioSentinel offers an extensive line of products for your botulinum neurotoxin (BoNT) detection needs. Whether determining the potency of BoNT pharmaceuticals, screening and characterizing BoNT inhibitors, or detecting and/or quantifying BoNT concentrations in food and environmental samples, BioSentinel’s assays have sensitivity levels equivalent or better than the mouse LD50 assay. Our fluorescent mix and read assays can be used in high-throughput formats and are able to detect multiple BoNT serotypes in a wide range of complex matrices with minimal equipment needs. BioSentinel’s BoNT detection assays are the new standard for quantifying pharmaceutical BoNT preparations.

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BoTest ® Botulinum Neurotoxin Detection Kits

These flexible assays provide real-time detection of BoNT proteolytic activity in an optimized reaction buffer. Intended uses include quantification and characterization of BoNT pharmaceutical preparations, drug discovery, high throughput screening applications, and real-time detection applications. Read more

BoTest ® Matrix Botulinum Neurotoxin Detection Kits

These serotype-specific assays are robust and sensitive tools for the detection and quantification of BoNT proteolytic activity contained in complex matrices such as pharmaceutical preparations, food samples, blood, and serum. These magnetic bead-based kits are sold as a combination of a serotype-specific Matrix BoNT Immunoprecipitation Kit and the appropriate BoTest® BoNT Detection Kit. Read more

Matrix Botulinum Neurotoxin Immunoprecipitation (IP) Kits

The BoNT Immunoprecipitation Kits can be purchased separately to immunoprecipitate, concentrate, and purify BoNT out of a variety of solutions including foods, culture supernatants, serum, and drug substances for user-defined analysis. For quantification of bound BoNT, we recommend the BoTest® Botulinum Neurotoxin Detection Kits described above. Read more

BoLISA ® Botulinum Neurotoxin Sandwich ELISAs

The BoLISA kits are serotype-specific and detect and quantify total BoNT mass from liquid matrices using a traditional sandwich ELISA approach. Read more

BoTest ® Drug Screening Services for discovery of BoNT antagonists

BioSentinel can screen drug libraries of nearly any size using our BoTest reagents. Please inquire for more information.

BoTest ® and BoLISA ® are registered trademarks of BioSentinel, Inc. All rights reserved.

Botulinum toxin is not supplied with any BioSentinel products.

All tests are for research use only: not for use in diagnostic procedures.